Patrick Gillevet, PhD, MD

Gillevet, Patrick 2016 120x160Dr. Gillevet have had extensive training in microbiology, biochemistry, molecular biology, bioinformatics, and molecular evolution. He a broad multidisciplinary background for working in the Human Genome project, the Microbiome project, and Systems Biology. This training played a key role during my tenure as the Technical Director for the Center of Prokaryotic Genome Analysis at the University of Illinois under the direction of Carl Woese (Crawfoord Laureate) where I worked on the Thermoccocus celer genome which was one of the first microbial genome projects.

From 1990-1993 I was Director of the Harvard Genome Laboratory at Harvard University under the direction of Wally Gilbert (Nobel Laureate) where he worked on the Mycoplasma capriclum genome. From 1993-1996 I directed the Core Sequencing Facility at the National Center for Human Genome Research under Francis Collins. I teach courses in Molecular Ecology, Molecular Evolution, and Systems Biology.

He is currently Professor in the Department of Biology and the Director of the Microbiome Analysis Center at George Mason University which is dedicated to scientific research in Molecular Ecology of the Human Microbiome, Phylogenomics, HIV infection, and human disease. We have developed a Multitag sequencing methodology that allows us to profile hundreds of samples at one time. We are using this technology and supporting Bioinformatics analysis to investigate various diseases associated with the human microbiome and human disease.
A major focus of MBAC research is the study of dysbiosis of the microbial communities (microbiomes) that reside in the human gut, mouth, urogenital, and respiratory tracts, to model the homeostatic interactions between microbiome function and human-derived gene expression. We define these functions and interactions as the “metabiome” and this represents an example where biological data and computational tools are brought together in the multidisciplinary field called Systems Biology. It has now become apparent that the human microbiome is implicated in social behavior, reproduction, growth, cognition, as well as many diseases. The human microbiome is an integral component of the human ecosystem and is a major driver of the system. In fact, one could even say that the human host is there merely to propagate the “selfish microbiome.”